The Dallas Mavericks will take on the San Antonio Spurs at 8. 30 p. m. ET on Wednesday at the American Airlines Center. Dallas is 18-16 overall and 9-8 at home, while San Antonio is 18-14 overall and 9-8 on the road. The Mavericks have won four of the last five games between the teams. Dallas is favored by four-points in the latest Mavericks vs. Spurs odds from William Hill Sportsbook, and the over-under is set at 226. Before entering any Spurs vs. Mavericks picks, youll want to see the NBA predictions from the advanced computer model at SportsLine. . . The SportsLine Projection Model simulates every NBA game 10,000 times, and it returned over $5,000 in profit on its top-rated NBA picks last season. The model is also up over $8,800 on top-rated NBA picks over the past two-plus seasons. Dating back to last season, it enters Week 12 of the 2020-21 NBA schedule on a stunning 87-52 roll on top-rated NBA picks against the spread. Anybody who has followed it has seen huge returns. . . Now, the model has set its sights on Mavericks vs. Spurs. You can head to SportsLine to see its picks. Here are several NBA betting lines for Mavericks vs. Spurs. . What you need to know about the Spurs. The Spurs lost their final game before the All-Star break, 107-102 to Oklahoma City last Wednesday. They committed 19 turnovers in the loss. San Antonio lost three of five games before the break. DeMar DeRozan scored 20 points in San Antonios loss against the Thunder. . . DeRozan, whos averaging 20. 0 points, 7. 2 assists and 4. 9 rebounds this season, scored 29 points in the most recent meeting with the Mavericks. The Spurs are 8-3 in their last 11 games on the road. However, San Antonio is just 1-4 in its last five meetings against Dallas. . . What you need to know about the Mavericks. Dallas won three straight and 10 of 13 overall before the All-Star break. The Mavericks won their final game before the break, 87-78 over Oklahoma City last Tuesday. Kristaps Porzingis had 19 points and 13 rebounds. Luka Doncic back missed that game but is expected to play on Wednesday. The Mavericks are 7-1 in their last eight games at home. The Mavericks beat the Spurs 122-117 in the last meeting on Jan. 22. Doncic scored 36 points in that game. For the season, Doncic is averaging 28. 6 points, 9. 0 assists and 8. 4 rebounds per game. . . How to make Mavericks vs. Spurs picks. The model has simulated Mavericks vs. Spurs 10,000 times and the results are in. We can tell you that the model is leaning under, and its also generated a point-spread pick that is hitting in almost 70 percent of simulations. You can only see the pick at SportsLine. .